During biofilm development, a large number of phenomena occur simultaneously and interact over a wide range of length and time scales. As a result of nutrient conversions, the biofilm expands on the basis of bacterial growth and production of extracellular polymeric substances (EPS). Chemical species need to be ontinuously transported to and from the biofilm system by physical processes such as olecular diffusion and convection. Fluid flow influences biofilm growth by determining the concentrations of available substrates and products. On the other hand, the flow also shears the biofilm surface, and determines biofilm detachment processes. In the case of multi-species systems, microorganisms of different species interact in complex relationships of competition or cooperation. All these linked phenomena create a dynamic picture of the biofilm three-dimensional (3D) structure. The large number of localized interactions poses an important challenge for experimentalists. Mathematical models can prove useful because they allow testing of hypotheses and, in addition, can direct experimental efforts to complex regions of operation that can easily confound the general intuition. Although the word “modeling” is used for different purposes, the final result is invariably the same: models are no more than a simplified representation of reality based on hypotheses and equations used to rationalize observations. By providing a rational environment, models can lead to deeper and more general understanding. Ultimately, understanding the underlying principles becomes refined to such a state that it is possible to make accurate predictions.
松本 慎也 論文題目「分子生物学的手法および数学モデルを併用したバイオフィルム微生物生理生態解析方法論の構築」 英文題目「Development of Methodology to Analyze Microbial Ecophysiology in Biofilms by Combining Molecular Biology Techniques and Mathematical Modeling」